Axis 2
Studiedness
- Evidence amount
- 0.96
- Direction balance
- The direction of the study results has not been extracted.
- PMID records loaded
- 9
- Records after title/year deduplication
- 9
entity · release 2026-09-20
Bacillus coagulans IS-2
Structured fields rendered from the release dataset. Unknown values retain a reason; price is outside GIS.
Across the corpus
How this organism is actually sold
- Printed CFU per serving
- 500,000,000 – 6,000,000,000; median 4,000,000,000. Measured on the 9 of 16 published products carrying it whose latest published label prints a figure for it; the rest print a blend total or no quantity, and earlier label versions in the table below may print other figures. 0 row(s) print a CFU below 1 000 and are excluded as a label or parsing artefact.
- Forms
- Capsule: 3 · Gummy or Jelly: 12 · Liquid: 1 · counted across the 16 of 16 published products whose label states a form
- Brands carrying it
- essential-source (1) · garden-of-life-mykind-organics (1) · master-supplements (1) · spring-valley (2) · sundown-kids (2) · the five largest of 14 brands with a published product
- Published product pages
- 16
Products
Published products carrying this organism
| Product | Printed CFU | Printed dose | Cost per day | Form | Gut Index Score |
|---|---|---|---|---|---|
| Nature's Way Primadophilus Fortify Gummy Probiotic Berry Flavored | 6,000,000,000 | not printed | not observed | Gummy or Jelly | 93.09 |
| Nature's Bounty Probiotic Gummies | 4,000,000,000 | not printed | not observed | Gummy or Jelly | 86.34 |
| Sundown Naturals Probiotic Gummies | 2,000,000,000 | not printed | not observed | Gummy or Jelly | 86.34 |
| NatureSmart Probiotic Gummies | 4,000,000,000 | not printed | not observed | Gummy or Jelly | 86.34 |
| Spring Valley Children's Probiotic Gummies | 5,000,000,000 | not printed | not observed | Gummy or Jelly | 81.84 |
| Spring Valley Probiotic Gummies | 500,000,000 | not printed | not observed | Gummy or Jelly | 81.84 |
| Equate Probiotic Gummies | 500,000,000 | not printed | not observed | Gummy or Jelly | 81.84 |
| Nature Made Digestive Probiotics + Energy B12 Dual Action | 4,000,000,000 | not printed | not observed | Gummy or Jelly | 81.84 |
| Inside Probiotic Bacillus Coagulans | not printed | not printed | not observed | Capsule | 81.84 |
| Garden of Life MyKind Organics Apple Cider Vinegar Probiotic Gummies | not printed | not printed | not observed | Gummy or Jelly | 72.78 |
| Garden of Life Dr. Fomulated Women's Probiotic Berry Flavor | not printed | not printed | not observed | Gummy or Jelly | 72.78 |
| Garden of Life Dr. Formulated Women's Probiotic Gummies Berry Flavor | not printed | not printed | not observed | Gummy or Jelly | 72.78 |
The 12 highest-scoring of 16 published products carrying it.
Reformulations
Label changes involving this organism
4 change(s) to this organism's own row, observed on 3 product(s). A change is counted only between two snapshots whose ingredient rows were both parsed; a first observation is not a change.
- Nature's Way Primadophilus Fortify Gummy Probiotic Berry Flavored: 78296 → 199521, printed CFU 4,000,000,000 → 6,000,000,000, potency basis unstated → through_expiry
- Sundown Naturals Probiotic Gummies: 63447 → 72217, printed CFU 2,000,000,000 → 4,000,000,000
- Sundown Naturals Probiotic Gummies: 72217 → 212219, printed CFU 4,000,000,000 → 2,000,000,000
- Equate Probiotic Gummies: 178781 → 211458, organism added to the label, potency basis at_manufacture → unstated
Containing labels32
Evidence amount0.96
Direction balanceThe direction of the study results has not been extracted.
Matched PubMed records
9 records (retracted records excluded; 0 retracted records match the query separately). PubMed query
Matched records include trials of multi-ingredient products; this is not a count of trials of this entity alone.
- 2025 · Bacillus coagulans Unique IS2 improves stool characteristics in healthy adults with infrequent bowel movements: a randomized, double-blind, placebo-controlled trial.
- 2023 · Effect of Bacillus coagulans Unique IS2 with Lactulose on Functional Constipation in Adults: a Double-Blind Placebo Controlled Study.
- 2022 · The effect of Bacillus coagulans Unique IS-2 supplementation on plasma amino acid levels and muscle strength in resistance trained males consuming whey protein: a double-blind, placebo-controlled study.
- 2021 · Effect of Multi-strain Probiotic Formulation on Students Facing Examination Stress: a Double-Blind, Placebo-Controlled Study.
- 2020 · Bacillus coagulans Unique IS2 in Constipation: A Double-Blind, Placebo-Controlled Study.
- 2019 · Effect of multi-strain probiotic (UB0316) in weight management in overweight/obese adults: a 12-week double blind, randomised, placebo-controlled study.
- 2019 · Efficacy of UB0316, a multi-strain probiotic formulation in patients with type 2 diabetes mellitus: A double blind, randomized, placebo controlled study.
- 2019 · Randomized clinical trial: the effect of probiotic Bacillus coagulans Unique IS2 vs. placebo on the symptoms management of irritable bowel syndrome in adults.
- 2018 · Efficacy of Bacillus coagulans Unique IS2 in treatment of irritable bowel syndrome in children: a double blind, randomised placebo controlled study.
ClinicalTrials.gov
0 interventional studies. ClinicalTrials.gov query
This species has 12 tracked designations; this one appears on 32 labels (median 3.5).
Other printed names
- Bacillus coagulans IS2
Species and related strains
Axis 1 · inverted
Containing label versions
Showing 32 of 32 rows, ordered by Gut Index Score descending, then DSLD label ID. Download full CSV · Download full JSON.
| Brand | Product | DSLD | Gut Index Score | Strain named | Per-organism quantity | Potency basis | Versions |
|---|---|---|---|---|---|---|---|
| Nature's Way | Fortify Gummy Probiotic 6 Billion Berry Flavored | 199521 | 93.09 | true | 6,000,000,000 CFU | through expiry | 3 |
| Nature's Way | Fortify Gummy Probiotic 6 Billion Berry Flavored | 251908 | 93.09 | true | 6,000,000,000 CFU | through expiry | 3 |
| Nature's Bounty | Probiotic Gummies | 62845 | 86.34 | true | 4,000,000,000 CFU | at manufacture | 7 |
| Sundown Naturals | Probiotic Gummies | 63447 | 86.34 | true | 2,000,000,000 CFU | at manufacture | 3 |
| NatureSmart | Probiotic Gummies | 63518 | 86.34 | true | 4,000,000,000 CFU | at manufacture | 1 |
| Nature's Bounty | Probiotic Gummies | 64458 | 86.34 | true | 4,000,000,000 CFU | at manufacture | 7 |
| Nature's Bounty | Probiotic Gummies | 64459 | 86.34 | true | 4,000,000,000 CFU | at manufacture | 7 |
| Nature's Bounty | Probiotic Gummies | 65691 | 86.34 | true | 4,000,000,000 CFU | at manufacture | 7 |
| Sundown Naturals | Probiotic Gummies | 72217 | 86.34 | true | 4,000,000,000 CFU | at manufacture | 3 |
| Nature's Bounty | Probiotics Gummies | 73305 | 86.34 | true | 4,000,000,000 CFU | at manufacture | 7 |
| Nature's Bounty | Probiotic Gummies | 74446 | 86.34 | true | 4,000,000,000 CFU | at manufacture | 7 |
| Sundown Kids | Probiotic Gummies | 212219 | 86.34 | true | 2,000,000,000 CFU | at manufacture | 3 |
| Nature's Bounty | Probiotic Gummies | 253081 | 86.34 | true | 4,000,000,000 CFU | at manufacture | 7 |
| Nature's Way | Primadophilus Fortify Gummy Probiotic Berry Flavored | 78296 | 81.84 | true | 4,000,000,000 CFU | not stated | 3 |
| Spring Valley | Children's Probiotic Gummies | 178562 | 81.84 | true | 7,500,000,000 CFU | not stated | 1 |
| Spring Valley | Probiotic Gummies | 178713 | 81.84 | true | 750,000,000 CFU | not stated | 1 |
| Nature Made | Digestive Probiotics + Energy B12 Dual Action | 180385 | 81.84 | true | 4,000,000,000 CFU | not stated | 1 |
| Equate | Probiotic Gummies | 211458 | 81.84 | true | 500,000,000 CFU | not stated | 2 |
| Inside | Probiotic Bacillus Coagulans | 302031 | 81.84 | true | not printed for this organism | not stated | 1 |
| Garden of Life MyKind Organics | Apple Cider Vinegar Probiotic Gummies | 243324 | 72.78 | true | not printed for this organism | not stated | 1 |
| Garden of Life Dr. Fomulated | Women's Probiotic Berry Flavor | 250114 | 72.78 | true | not printed for this organism | not stated | 1 |
| Garden of Life MyKind Organics | Organic Apple Cider Vinegar Gummies 2 BIL CFU | 273812 | 72.78 | true | not printed for this organism | not stated | 1 |
| Garden of Life Dr. Formulated | Women's Probiotic Gummies Berry Flavor | 297659 | 72.78 | true | not printed for this organism | not stated | 1 |
| Sundown Kids | Probiotic + Immune Gummies | 252492 | 70.59 | true | not printed for this organism | not stated | 1 |
| Mary Ruth’s | Organic Infant Liquid Probiotic 100 Million CFU Unflavored | 327722 | 61.75 | true | not printed for this organism | not stated | 1 |
| Master Supplements | TruFlora | 336273 | 47.36 | true | 2,000,000,000 CFU | not stated | 1 |
| Essential Source | TriActive Biotics for Women | 317925 | 40.61 | true | not printed for this organism | at manufacture | 1 |
| TruDerma | Active Probiotic | 71066 | Not available in this release. | true | undefined: light snapshot | not stated | 1 |
| Mary Ruth’s | CoComelon Toddler Probiotic Liquid Drops Unflavored | 327714 | Not available in this release. | true | undefined: light snapshot | not stated | 1 |
| Nature's Way | Women's 3-in-1 Probiotic Gummy Orange Flavored | 328090 | Not available in this release. | true | undefined: light snapshot | not stated | 1 |
| Nature's Way | Women's 3-in-1 Probiotic Gummy Orange Flavored | 332954 | Not available in this release. | true | undefined: light snapshot | not stated | 1 |
| Inside | Probiotic 15 Billion Microflora | 336606 | Not available in this release. | true | undefined: light snapshot | not stated | 1 |
Axis 3
Measurement integrity
Not a measurement product, so this axis does not apply.
Axis 4
Reddit mention panel
0 observed mentions; no aggregate panel matched this entity.
Products
Also carried by
4 further published products carry it beyond the table above.
Sundown Kids Probiotic + Immune Gummies · Mary Ruth’s Organic Infant Liquid Probiotic 100 Million CFU Unflavored · Master Supplements TruFlora · Essential Source TriActive Biotics for Women
Elsewhere in this release
Related pages
Findings computed over the whole corpus: Strain naming census · Label designation changes · Strain dose match · Stability literature gaps
Tools: DSLD product check · Unit value calculator
Citation
Cite this page
Ivitskiy, I. (2026). Bacillus coagulans IS-2. Gut Registry, release 2026-09-20. Elanvale Ltd. https://gutregistry.com/s/bacillus-coagulans-is-2/
The underlying tables are published under CC BY 4.0: this page as CSV · as JSON · full release and data dictionary. Cell-level provenance names the source record and its observation date.
Citable atoms
Release claims
Bacillus coagulans IS-2 appears on 32 of 13,330 labels in the NIH DSLD snapshot (Sep 2026), from 17 brands; rank 51 of 692 designations by distinct label count.
32 / 13330 observed label versions · NIH DSLD snapshot Sep 2026 · entity.prevalence · checked 2026-09-20T00:00:00Z · snapshot b7633f73243720 of 32 containing labels in the NIH DSLD snapshot (Sep 2026) print a quantity for Bacillus coagulans IS-2 (62.5%); 5 light records have quantities unavailable.
20 / 32 containing labels · NIH DSLD snapshot Sep 2026 · entity.quantity · checked 2026-09-20T00:00:00Z · snapshot b7633f7324379 PubMed records indexed as human randomized controlled trials match the published query (as of 2026-09-15). 9 records (retracted records excluded; 0 retracted records match the query separately).
9 / 9 loaded PMID records · NIH DSLD snapshot Sep 2026 · entity.evidence · checked 2026-09-20T00:00:00Z · snapshot b7633f7324370 interventional studies on ClinicalTrials.gov match the published query.
Published ClinicalTrials.gov query
0 / Not available in this release. interventional registry studies · NIH DSLD snapshot Sep 2026 · entity.registered_trials · checked 2026-09-20T00:00:00Z · snapshot b7633f7324370 of 22 SKUs containing Bacillus coagulans IS-2 have a numeric price observation (0.0%) in the release accompanying the NIH DSLD snapshot Sep 2026.
0 / 22 containing SKUs · NIH DSLD snapshot Sep 2026 · entity.price · checked 2026-09-20T00:00:00Z · snapshot b7633f732437